A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

Abstract Background Copy number variation (CNV) is an important source of genetic that has a significant influence on phenotypic diversity, economically traits and the evolution livestock species. In this study, genome-wide CNV distribution characteristics 32 fine-wool sheep from three breeds were analyzed using resequencing. Results A total 1,747,604 CNVs detected in 7228 regions (CNVR) obtained after merging overlapping CNVs; these accounted for 2.17% reference genome. The average length CNVRs was 4307.17 bp. “Deletion” events took place more frequently than “duplication” or “both” events. overlapped with previously reported to variable extents (4.39–55.46%). Functional enrichment analysis showed CNVR-harboring genes mainly involved sensory perception systems, nutrient metabolism processes, growth development processes. Furthermore, 1855 associated 166 quantitative trait loci (QTL), including milk QTLs, carcass health-related among others. addition, divided into horned polled groups analyze selective sweep CNVRs, it found relaxin family peptide receptor 2 ( RXFP2 ) gene strongly influenced by selection. Conclusions summary, we constructed genomic map Chinese indigenous resequencing, thereby providing valuable resource genome research, which will contribute study complex sheep.